1. Methyl silicone oil - used as a release agent in the production process of suppositories and other preparations

The preparation of suppository refers to a kind of preparation for cavity that the medicine and matrix are melted, poured into the suppository mold while hot, cooled and formed, and then scraped out.

Dimethicone and liquid paraffin are commonly used as release agents for water-soluble suppository products; dimethicone is a non-petrochemical product to reduce the possible risk of allergic reactions, irritation and other reactions.

Suppositories based on poloxamer must use simethicone as a release agent because poloxamer is hygroscopic.

2. Methyl silicone oil - used as a lubricant in solid preparations

Lubricant refers to the general term for the auxiliary materials that are added to the material to be compressed before tableting to make it have or increase fluidity, anti-adhesion and lubricity, so as to facilitate the tableting process. According to the mechanism of action of lubricants, they are divided into three types; lubricants refer to the auxiliary materials that can reduce the friction between granules or tablets and the die.

After the tablet punch is cleaned, a layer of simethicone can also solve the problem of sticking and punching of some varieties.

1. Sustained release aspirin tablets

Take 1000g of aspirin powder (crystal diameter is 0.1770mm), 70g of ethoxyethyl cellulose (containing 12% ethoxylate), dissolved in 300ml (1:1) solution of toluene-dichloromethane and dimethyl silicone oil 30 g of toluene solution, 400 g of starch, 300 g of glyceryl palmitate stearic fatty acid ester, 50 g of talc, and 100 g of microcrystalline cellulose are prepared into tablets by the usual method.

2. Compound Paracetamol Capsules

The aspirin granules were heated to 50°C, coated with a 1:1 copolymer of methacrylic acid and methacrylate and 0.045% AF emulsion (defoamer), dried at 37.8°C for more than 24 hours in a fluidized drying bed, and then Weigh 52.144 g, add 0.203 g of sodium lauryl sulfate, 41.45 g of paracetamol, 0.363 g of dimethicone, and 0.145 g of polyoxyethylene dehydrated monooleate, mix well, and put into capsules. Capsules weigh 700 mg, each containing 325 mg of aspirin and 325 mg of paracetamol.

3. Ibuprofen Sustained Release Tablets

Take ibuprofen 58.25%, lactose 14.50%, calcium hydrogen phosphate 12.60%, glyceryl behenate 11.65%, magnesium stearate 1.0%, talc+silicone oil (4:1) 2.0% to make tablets by conventional method.

Co-Formula's commercial products include isocyanate silanes, amino silanes, epoxy silanes, mercapto silanes, phenyl silanes, vinyl silanes, chlorosilanes, alkyl silanes, long chain silanes, silane crosslinkers, dimethicone, methyl silane Hydrogen based silicone oil and bi-end type siloxane. In addition to these general-purpose products, Co-Formula can also provide coatings and plastic additives, silicone polymers, and custom solutions for customers worldwide. If necessary, welcome to consult.