Preparation of Silane Coupling Agent CFS-611

In the 500Ml reactor with snake-type condenser, electric stirrer, dropping funnel, thermometer, heater, add 200Ml of tetrahydrofuran, 12g magnesium, 6g of chloropropene (the remaining 40g of chloropropene is added in the dropping funnel) , Under stirring, slowly heat to initiate the reaction, and control the reaction temperature to 50-75 C. Once the reaction is initiated, stop heating immediately. If the reaction is violent, quickly cool the reaction kettle. After the reaction is stable, open the dropping funnel and drop drops into the reaction kettle. Add chloropropene, dropwise addition, drop to room temperature, then add 0.2g sodium thiocyanate Chemicalbook and 0.2g cuprous chloride catalyst to the reaction kettle, add 127g diphenyldichlorosilane to the dropping funnel, and under stirring Add diphenyldichlorosilane dropwise into the reaction kettle, after the dropwise addition is completed, the materials in the reaction kettle are heated to 90-150 C, and the reaction is performed at a constant temperature for 4-7 hours. Toluene, stir evenly, the resulting liquid is filtered to remove solid salts, the filtrate is distilled, the flux is evaporated, and then vacuum distillation is carried out, under 0.09Kpa, the fractions at 200C are collected to obtain a product with a content of 98% tert-butyldiphenylchlorosilane .

Application of Silane Coupling Agent CFS-661

1. Silane coupling agent CFS-661, Tert-butyldiphenyl chlorosilane, also known as silane protective agent, its function is to replace the active hydrogen in the silyl group (such as the hydrogen in the hydroxyl group, carboxyl group and amino group) to generate a stable intermediate; then, the intermediate The other groups of the compound undergo some reactions; after the reaction, the silyl group is removed through the chemicalbook perhydrolysis reaction, and the group originally protected by the silyl group is regenerated to synthesize some specific compounds. Due to the high conversion rate and even quantitative reaction of silane protection and deprotection reactions, it is widely used in organic synthesis, especially in drug synthesis.

2. Silane coupling agent CFS-661, Tert-butyldiphenylchlorosilane is used to synthesize p-benzophenyloxazole, which is a compound with antagonistic activity to thromboxane receptors, which can be used to treat circulatory system diseases, angina pectoris and stroke.

3. Silane coupling agent CFS-661 can be used as pharmaceutical intermediates and used in organic synthesis.

4. Silane coupling agent CFS-661 is a kind of silicon-based protecting group; used in the synthesis of pharmaceutical intermediates or other macromolecules.

5. Silane coupling agent CFS-661 can be used as silanating reagents for protecting alcohols and preparing silyl ethers.

6. Silane coupling agent CFS-661 can be used as silicating agents for protecting alcohols and preparing silyl ethers.